Histone methylation regulates normal stem cell fate decisions through a coordinated interplay between histone methyltransferases and demethylases at lineage specific genes. Malignant transformation is associated with aberrant accumulation of repressive histone modifications. such as polycomb mediated histone 3 lysine 27 (H3K27me3) resulting in a histone methylation mediated block to d... https://thebrickes.shop/product-category/donation/